منابع مشابه
Choline Metabolism: Meaning and Significance
Choline is an essential nutrient Choline (Cho), a quaternary amine, is an essential nutrient supplied by the diet (1, 2). Choline uptake and intracellular metabolism during the prenatal period were shown to have a critical role in brain development and cognitive processes (3, 4). Choline is a precursor in several key biochemical pathways as demonstrated below in scheme 1. Scheme 1: Metabolic Fa...
متن کاملGenetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations
Single nucleotide polymorphisms (SNPs) in choline metabolizing genes are associated with disease risk and greater susceptibility to organ dysfunction under conditions of dietary choline restriction. However, the underlying metabolic signatures of these variants are not well characterized and it is unknown whether genotypic differences persist at recommended choline intakes. Thus, we sought to d...
متن کاملEffect of Cycocel derivatives and gibberellin on choline kinase and choline metabolism.
Cycocel stimulated the activity of partial purified choline kinase from spinach or squash leaves, but it inhibited the activity of yeast choline kinase. The activity of different Cycocel analogs on plant growth corresponded to their stimulatory effect on the isolated choline kinase. Cycocel had no effect upon the activity of a plant phosphatase which hydrolyzed phosphorylcholine nor upon adenos...
متن کاملProtein metabolism in the choline-deficient rat. I. Effect of choline on serum proteins.
Unless the choline content is sufficient to supply all of the required methyl groups, the amount of choline in a diet apparently determines the quantity of methionine used for protein synthesis and the quantity reserved for use as a methyl donor. This concept is supported by Treadwell’s demonstration (1) of the growth-stimulating effect of choline and Salmon’s observation (2) that the nutritive...
متن کاملMetabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis.
Specific genetic alterations during malignant transformation may induce the synthesis and breakdown of choline phospholipids, mediating transduction of mitogenic signals. The high level of water-soluble choline metabolites in cancerous breast tumors, relative to benign lesions and normal breast tissue, has been used as a diagnostic marker of malignancy. To unravel the biochemical pathways under...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1940
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)56211-1